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The effect is usually most pronounced during the first several weeks and in the days after each dose increase, and it often eases as the body adapts and intake habits stabilize
Among the remaining subjects, we further excluded those who received a diagnosis of bipolar disorder during the follow-up assessment (n = 9), those with missing metabolite data due to the lack of blood samples (n = 158) and those who did not complete the Inventory for Depressive Symptoms questionnaire (n = 33)
C.et al (20182018)
